Table 3.

Interactions between CSF VEGF levels and CSF t-tau and p-tau on FDG-PET ROIs (n=158)

	VEGF × t-tau				VEGF × p-tau
ROI	β	SE	p-value	FDR-p-value	β	SE	p-value	FDR-p-value
Superior Temporal Gyrus	0.001	0.001	0.225	0.29	0.005	0.004	0.202	0.227
Middle Temporal Gyrus	0.003	0.001	0.008	0.037*	0.010	0.002	0.015	0.029*
Inferior Temporal Gyrus	0.003	0.001	0.028	0.051	0.011	0.004	0.010	0.029*
Fusiform Gyrus	0.0009	0.001	0.44	0.495	0.007	0.004	0.085	0.127
Entorhinal Cortex	−0.00003	0.001	0.97	0.97	0.004	0.004	0.270	0.270
Superior Parietal Cortex	0.003	0.001	0.026	0.051	0.01	0.005	0.009	0.029*
Inferior Parietal Cortex	0.004	0.002	0.008	0.037*	0.013	0.005	0.013	0.029*
Posterior Cingulate	0.003	0.002	0.067	0.10	0.008	0.006	0.153	0.197
Precuneus	0.004	0.002	0.028	0.051	0.016	0.006	0.016	0.029*

Each association was evaluated using a linear mixed effects model. Fixed effects included CSF VEGF, age, sex, years of education, and CSF Aβ, APOE4, and diagnosis. Site was modeled using random effects.

SE = Standard Error; FDR = False Discovery Rate.

^*indicates p< 0.05 significance