Table 5.

Regional mediation effects in Aβ+ participants (n=116)

Mediational Process	Inferior Temporal Gyrus			Middle Temporal Gyrus			Inferior Parietal Cortex
	β	95% CI	p-value	β	95% CI	p-value	β	95% CI	p-value
CSF VEGF → FDG-PET SUVR ROI → ADNI-EF
Indirect effect	0.54	(0.14, 1.08)	0.006*	0.35	(0.05, 0.78)	0.016*	0.59	(0.14, 1.22)	0.010*
Direct effect	1.11	(−0.03, 2.16)	0.060	1.25	(0.16, 2.41)	0.026*	1.07	(0.07, 2.12)	0.036*
Total effect	1.65	(0.51, 2.73)	0.002*	1.60	(0.48, 2.80)	0.006*	1.66	(0.59, 2.84)	0.002*
Proportion Mediated	0.33	(0.09, 1.05)	0.008*	0.21	(0.03, 0.70)	0.022*	0.36	(0.10, 0.90)	0.012*

ROI = Region of Interest.

^*p< 0.05 significance