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. 2021 Nov;27(11):2971–2973. doi: 10.3201/eid2711.211575

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Intra-island spread and divergence of Zika virus, Puerto Rico, 2016–2017. Bayesian phylogenetic reconstruction using maximum clade credibility trees shows genomes grouping with 2 separate clusters. PR C1 is associated with genomes from South America and the Caribbean (top); this clade diverged into SC1 and SC2. PR C2 is associated with genomes from Central America (center). Epidemic curve of total Zika cases per week (orange shade) and cases confirmed by reverse transcription PCR per week (blue shade) during 2015–2017 (bottom). All external branches representing Puerto Rico genomes are color-coded according to the 8 health regions of Puerto Rico: region 1, red; region 2, blue; region 3, orange; region 4, green; region 5, purple; region 6, cyan; region 7, brown; and region 8, magenta. C, clade; PR, Puerto Rico; SC, subclade; tMRCA, time of most recent common ancestor.