Table 2.
Association of cerebral perfusion with age, sex, and APOE ε4 status (n = 950).
| Total gray mattera | Hippocampusa | Superior frontal gyrusa | Middle frontal gyrusa | Posterior cingulatea | Precuneusa | |
|---|---|---|---|---|---|---|
| Linear model, 5-yrs | ||||||
| Age, 5-year | −1.43** (−1.79, −1.07) |
−1.25** (−1.70, −0.80) |
−1.70** (−2.18, −1.22) |
−1.99** (−2.52, −1.46) |
−2.46** (−3.26, −1.67) |
−2.14** (−2.76, −1.52) |
| Categorical age | ||||||
| Age groups | ||||||
| 40–49 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
| 50–59 | −3.10** (−5.03, −1.18) |
−3.18** (−5.13, −1.23) |
−2.89** (−5.00, −0.78) |
−3.26** (−5.57, −0.95) |
−5.76** (−9.16, −2.36) |
−4.95** (−7.63, −2.26) |
| 60–69 | −4.72** (−6.87, −2.57) |
−4.42** (−6.72, −2.13) |
−4.88** (−7.37, −2.38) |
−5.62** (−8.35, −2.90) |
−7.99** (−12.00, −3.99) |
−7.40** (−10.57, −4.23) |
| ≥70 | −7.10** (−9.64, −4.58) |
−6.37** (−9.25, −3.49) |
−7.12** (−10.26, −3.99) |
−8.23** (−11.66, −4.81) |
−11.68** (−16.66, −6.69) |
−10.46** (−14.43, −6.50) |
| APOE ε4 | ||||||
| Age× APOE ε4 | 0.21 (−0.36, 0.79) |
0.05 (−0.61, 0.71) |
0.08 (−0.62, 0.79) |
0.11 (−0.66, 0.87) |
0.00 (−1.16, 1.17) |
0.20 (−0.71, 1.11) |
| Sex | ||||||
| Age×Sex | −0.37 (−0.95, 0.20) |
−0.11 (−0.75, 0.54) |
−0.53 (−1.23, 0.16) |
−0.65 (−1.41, 0.11) |
−0.64 (−1.80, 0.51) |
−0.82 (−1.72, 0.07) |
| APOE ε4 and sex | ||||||
| Age×ε4×Sex | −1.23* (−2.46, −0.03) |
−1.52* (−2.98, −0.12) |
−1.61* (−3.10, −0.11) |
−1.85* (−3.49, −0.21) |
−1.96 (−4.45, 0.52) |
−1.70 (−3.64, 0.24) |
aThe β-coefficients and 95% confidence intervals in the models were adjusted for birth cohort, sex, APOE ε4 status, education, parental history of dementia, smoking status, intracranial volume, post-labeling delay, and head coil.
*0.01<p < 0.05; **p < 0.01.