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. 2021 Oct 11;12:741513. doi: 10.3389/fimmu.2021.741513

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Copyright © 2021 Seppo, Choudhury, Pizzarello, Palli, Fridy, Rajani, Stern, Martina, Yonemitsu, Bode, Bu, Tamburini, Piras, Wallach, Allen, Looney, Clemente, Thakar and Järvinen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of IgA₁ and IgA₂ responses in human milk. Hierachial clustering of IgA₁ levels depicting correlation between antigen-specific IgA1 (A) and IgA2 levels (C). (B) Stacked bar plot of IgA₁ levels normalized between 0 and 1 depicting higher accumulated levels of IgA₁ in OOM. (D) Stacked bar plot of IgA₂ levels normalized between 0 and 1 depicting higher accumulated levels of IgA₂ in Rochester. IgA2 levels to bacteria antigens were too low to graph. D.p., Dermatophagoides pteronyssinus; d.f, Dermatophagoides farina. * indicates statistically significant correlation with p<0.001.