Table 2.
Multivariate analysis incorporating specific IgA levels, BMI, lifestyle, antibiotic use, age, atopy, cats, dogs, and parity.
Lifestyle | Parity | BMI | Mother age (years) | Antibiotic use | Mother’s atopy | Cat in the household | Dog in the household | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
p-Value | t-Value | p-Value | t-Value | p-Value | t-Value | p-Value | t-Value | p-Value | t-Value | p-Value | t-Value | p-Value | t-Value | p-Value | t-Value | |
IgA | ||||||||||||||||
β-lactoglobulin IgA2 | 0.401 | −2.318 | 0.006 | −0.859 | 0.809 | −3.082 | 0.048 | −0.245 | 0.118 | 2.104 | 0.674 | −1.634 | 0.612 | 0.515 | 0.357 | 0.944 |
S. equis IgA1 | 0.174 | −0.648 | 0.336 | −1.393 | 0.794 | −0.978 | 0.995 | 0.264 | 0.366 | 0.006 | 0.138 | −0.918 | 0.035 | 2.210 | 0.075 | 1.847 |
Casein IgA1 | 0.033 | 1.739 | 0.218 | 2.246 | 0.080 | 1.261 | 0.315 | −1.816 | 0.284 | −1.024 | 0.787 | 1.093 | 0.562 | 0.588 | 0.074 | 1.861 |
Cytokines | ||||||||||||||||
APRIL | 0.478 | −0.722 | 0.284 | −1.099 | 0.873 | −0.162 | 0.350 | 0.956 | 0.033 | −2.278 | 0.229 | −1.239 | 0.491 | −0.701 | 0.519 | −0.656 |
BAFF | 0.760 | −0.310 | 0.385 | −0.887 | 0.628 | 0.492 | 0.827 | 0.221 | 0.547 | −0.613 | 0.041 | −2.175 | 0.952 | 0.061 | 0.831 | −0.217 |
IFN-λ3 | 0.038 | 2.213 | 0.830 | 0.217 | 0.286 | −1.095 | 0.528 | −0.642 | 0.144 | −1.518 | 0.542 | −0.620 | 0.612 | 0.516 | 0.540 | −0.623 |
sTNF.R1 | 0.052 | −2.056 | 0.014 | −2.672 | 0.480 | 0.719 | 0.065 | 1.950 | 0.040 | −2.188 | 0.454 | −0.763 | 0.526 | −0.645 | 0.507 | −0.674 |
TGF-β2 | 0.058 | −2.001 | 0.013 | −2.731 | 0.783 | 0.279 | 0.052 | 2.057 | 0.245 | −1.197 | 0.294 | −1.076 | 0.508 | −0.674 | 0.861 | 0.178 |
Human milk oligasaccharides (HMOs) | ||||||||||||||||
LNnT | 0.403 | −0.860 | 0.919 | −0.104 | 0.423 | −0.823 | 0.670 | −0.435 | 0.017 | −2.688 | 0.436 | 0.801 | 0.158 | −1.487 | 0.773 | −0.294 |
DFLac | 0.208 | 1.314 | 0.249 | 1.198 | 0.103 | 1.738 | 0.289 | −1.099 | 0.044 | 2.203 | 0.329 | −1.010 | 0.184 | −1.392 | 0.287 | 1.103 |
6.SL | 0.023 | −2.532 | 0.015 | −2.759 | 0.129 | 1.607 | 0.302 | 1.069 | 0.780 | −0.285 | 0.060 | 2.037 | 0.304 | 1.065 | 0.084 | −1.848 |
LNFP.I | 0.982 | 0.023 | 0.837 | 0.210 | 0.314 | −1.042 | 0.221 | −1.278 | 0.031 | −2.386 | 0.196 | 1.353 | 0.331 | 1.006 | 0.498 | 0.695 |
LNFP.II | 0.106 | 1.720 | 0.193 | 1.364 | 0.510 | 0.675 | 0.253 | −1.188 | 0.045 | 2.188 | 0.742 | −0.335 | 0.287 | −1.103 | 0.810 | −0.245 |
DSLNT | 0.585 | 0.558 | 0.955 | −0.057 | 0.243 | −1.216 | 0.085 | −1.843 | 0.473 | −0.736 | 0.030 | 2.389 | 0.716 | −0.371 | 0.684 | −0.415 |
S. equis, Streptococcus equis. Bold font indicates p < 0.05.