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. 2021 Oct 11;12:741513. doi: 10.3389/fimmu.2021.741513

Table 2.

Multivariate analysis incorporating specific IgA levels, BMI, lifestyle, antibiotic use, age, atopy, cats, dogs, and parity.

Lifestyle Parity BMI Mother age (years) Antibiotic use Mother’s atopy Cat in the household Dog in the household
p-Value t-Value p-Value t-Value p-Value t-Value p-Value t-Value p-Value t-Value p-Value t-Value p-Value t-Value p-Value t-Value
IgA
β-lactoglobulin IgA2 0.401 −2.318 0.006 −0.859 0.809 −3.082 0.048 −0.245 0.118 2.104 0.674 −1.634 0.612 0.515 0.357 0.944
S. equis IgA1 0.174 −0.648 0.336 −1.393 0.794 −0.978 0.995 0.264 0.366 0.006 0.138 −0.918 0.035 2.210 0.075 1.847
Casein IgA1 0.033 1.739 0.218 2.246 0.080 1.261 0.315 −1.816 0.284 −1.024 0.787 1.093 0.562 0.588 0.074 1.861
Cytokines
APRIL 0.478 −0.722 0.284 −1.099 0.873 −0.162 0.350 0.956 0.033 −2.278 0.229 −1.239 0.491 −0.701 0.519 −0.656
BAFF 0.760 −0.310 0.385 −0.887 0.628 0.492 0.827 0.221 0.547 −0.613 0.041 −2.175 0.952 0.061 0.831 −0.217
IFN-λ3 0.038 2.213 0.830 0.217 0.286 −1.095 0.528 −0.642 0.144 −1.518 0.542 −0.620 0.612 0.516 0.540 −0.623
sTNF.R1 0.052 −2.056 0.014 −2.672 0.480 0.719 0.065 1.950 0.040 −2.188 0.454 −0.763 0.526 −0.645 0.507 −0.674
TGF-β2 0.058 −2.001 0.013 −2.731 0.783 0.279 0.052 2.057 0.245 −1.197 0.294 −1.076 0.508 −0.674 0.861 0.178
Human milk oligasaccharides (HMOs)
LNnT 0.403 −0.860 0.919 −0.104 0.423 −0.823 0.670 −0.435 0.017 −2.688 0.436 0.801 0.158 −1.487 0.773 −0.294
DFLac 0.208 1.314 0.249 1.198 0.103 1.738 0.289 −1.099 0.044 2.203 0.329 −1.010 0.184 −1.392 0.287 1.103
6.SL 0.023 −2.532 0.015 −2.759 0.129 1.607 0.302 1.069 0.780 −0.285 0.060 2.037 0.304 1.065 0.084 −1.848
LNFP.I 0.982 0.023 0.837 0.210 0.314 −1.042 0.221 −1.278 0.031 −2.386 0.196 1.353 0.331 1.006 0.498 0.695
LNFP.II 0.106 1.720 0.193 1.364 0.510 0.675 0.253 −1.188 0.045 2.188 0.742 −0.335 0.287 −1.103 0.810 −0.245
DSLNT 0.585 0.558 0.955 −0.057 0.243 −1.216 0.085 −1.843 0.473 −0.736 0.030 2.389 0.716 −0.371 0.684 −0.415

S. equis, Streptococcus equis. Bold font indicates p < 0.05.