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. 2021 Oct 11;12:674095. doi: 10.3389/fphar.2021.674095

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Copyright © 2021 Korinek, Handoussa, Tsai, Chen, Chen, Chiou, Fang, Chang, Yen, Hsieh, Chen, El-Shazly and Hwang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of PKA inhibitor H89 on FEN- and CUMIN-caused inhibition of superoxide generation in human neutrophils. H89 (3 μM) were preincubated for 5 min before the addition of fennel (FEN) or cumin (CUMIN) volatile oils (30 μg/ml). Superoxide generation was induced by FMLP/CB and measured using SOD-inhibitable cytochrome c reduction (details in Measurement of Superoxide Generation). ***p < 0.001 compared with the control group (fMLF/CB control). #p < 0.05, ##p < 0.05 compared with the control group (CUMIN- or FEN-inhibited superoxide generation).