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Mutation of the putative nucleolar retention signal modulates Cp-Y132A dimer localization. HuH7-H1 cells were transfected with 100 ng of EL43-Y132A or mutant proteins for 16 h and immunostained. The Y132A Cp mutation results in a defect that blocks capsid assembly. L31S and R98A mutations abrogated Cp-Y132A dimer localization to the nucleolus, while the L101S mutant was ineffective.
