TABLE 3.
Histopathology observations in kidney
| Pathology | Males (5 per group examined) |
Females (5 per group examined) |
||||
|---|---|---|---|---|---|---|
| Vehicle | CRMb | P*17/K4S2 | Vehicle | CRMb | P*17/K4S2 | |
| Day 46 observationsa | ||||||
| Within normal limits (no.) | 2 | 2 | 3 | 4 | 4 | 4 |
| Cast; minimal (no.) | 1 | 0 | 0 | 0 | 0 | 0 |
| Chronic progressive nephropathy, minimal (no.) | 3 | 2 | 2 | 1 | 1 | 0 |
| Chronic progressive nephropathy, mild (no.) | 0 | 1 | 0 | 0 | 0 | 0 |
| Mineralization, minimal (no.) | 0 | 0 | 0 | 0 | 0 | 1 |
| Mineralization, mild (no.) | 0 | 0 | 0 | 1 | 0 | 0 |
| Day 70 observationsa | ||||||
| Within normal limits (no.) | 3 | 4 | 3 | 4 | 4 | 4 |
| Chronic progressive nephropathy, minimal (no.) | 1 | 1 | 1 | 1 | 0 | 1 |
| Chronic progressive nephropathy, mild (no.) | 1 | 0 | 0 | 0 | 0 | 0 |
| Dilation; tubular, focal, mild (no.) | 0 | 0 | 2 | 0 | 1 | 0 |
a
Number of animals observed with pathology.
b
CRM, cross-reacting material.