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. 2021 Feb 23;12(1):e03690-20. doi: 10.1128/mBio.03690-20

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Copyright © 2021 Morgan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Cryo-EM structures of AdeB-I, AdeB-II, and AdeB-III. (A) Ribbon diagram of the structure of the side view (viewed in the membrane plane), top view (viewed from the extracellular space), and bottom view (viewed from the cytoplasm) of the AdeB-I trimer. A cartoon indicating the trimer configuration at the transmembrane domain is included. (B) Ribbon diagram of the structure of the side view, top view, and bottom view of the AdeB-II trimer. A cartoon indicating the dimer plus monomer configuration at the transmembrane domain is included. (C) Ribbon diagram of the structure of the side view, top view, and bottom view of the AdeB-III trimer. A cartoon indicating the monomer plus monomer plus monomer configuration at the transmembrane domain is included. In panels A to C, the AdeB extrusion protomers are colored blue, green, and pink, respectively. Each protomer creates an extrusion channel (colored yellow) for drug export. The switch in configuration of the trimeric AdeB pump from trimer (A) to dimer plus monomer (B) and monomer plus monomer plus monomer (C) may alter the interactions between the AdeB pump and AdeA adaptor at the protein-protein interface.