Dromerick 2009.

Study characteristics
Methods	RCT Adaptively randomised balancing age, NIHSS score, pretest ARAT, and days from stroke Study compared 2 different CIMT protocols to control. For this Cochrane Review, we were interested in the 2 different protocols for CIMT only (excluding control)
Participants	52 participants in 3 study arms Low CIMT:  n= 19; mean age 62.8 years; 68% female; 8.8 days poststroke High CIMT: n = 16; mean age 64.5 years; 44% female; 9.9 days poststroke Inpatient rehabilitation setting
Interventions	Intervention was CIMT Prespecified treatment (pre‐empted OT) based on Excite + RPT Received extensive verbal and written feedback and review of prior day's achievements, day's goals and reinforcement of new gains and maintenance Low CIMT: 2 hours of shaping therapy per day and padded constraint mitt for 6 hours per day High CIMT: 3 hours of shaping therapy per day and padded constraint mitt for 90% of waking hours Study treatment occurred 5 days per week for 2 weeks (consecutively)
Outcomes	NIHSS ARAT FIM SIS hand function subscale Pain ratings Geriatric Depression Scale All measures were taken on baseline, at 14 days (postintervention) and at 90 days
Notes	Conflict of interests:  authors disclosed the following:  Dr Dromerick has received research support from NIH, NINDS, and United States Veterans Affairs, and Intramural support from the United States Army, Department of Defense. Dr Lang has received research support from NIH, NINDS, and the Missouri Physical Therapy Association. Dr Miller has served on the Data and Safety Monitoring Board for Ethicon. Dr Powers has received research support from University of North Carolina, Washington University, University of Iowa, University of Kentucky, Harvard University, Bowdoin College, NIH, Legatus Emergency Services, LLC, Neutral, LLC, EDJ Associates, Hitchcock Foundation, Dartmouth‐Hitchcock Clinic, Certus International, Inc., Companion Baking Company, and Union Square Hospitality Group. Dr Wolf is supported by NIH, Allergan, and AMES Funding: NIH grant 1 RO1 NS41261‐01A1 and James S. McDonnell Foundation grant 21002032