| Cilostazol |
O=C1CCC2=C(N1)C=CC(OCCCCC1=NN=NN1C1CCCCC1)=C2 |
53.1 |
– |
100 mg twice/daily |
| Baricitinib |
CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 |
59.2 |
Clinical trials, [49], [50]
|
2 mg once / daily |
| Fluconazole |
OC(CN1C=NC=N1)(CN1C=NC=N1)C1=C(F)C=C(F)C=C1 |
64.34 |
– |
100 - 400 mg/daily |
| Itraconazole |
CCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1 |
70.3 |
– |
100 - 400 mg/daily |
| Quercetin |
OC1=CC2=C(C(O)=C1)C(=O)C(O)=C(O2)C1=CC=C(O)C(O)=C1 |
79.24 |
Clinical trial, [57]
|
500 −1000 mg/daily |
| Rabeprazole |
[Na+].COCCCOC1=CC=NC(CS(=O)C2=NC3=CC=CC=C3[N-]2)=C1C |
85.2 |
Clinical trial |
120 mg/daily |
| Grazoprevir |
COC1=CC2=NC3=C(CCCCC[C@@H]4C[C@H]4OC(=O)N[C@H](C(=O)N4C[C@@H](C[C@H]4C(=O)N[C@@]4(C[C@H]4C=C)C(=O)NS(=O)(=O)C4CC4)O3)C(C)(C)C)N=C2C=C1 |
98.47 |
[51] |
100 mg/day |
| Abacavir (sulfate) |
OS(O)(=O)=O.NC1=NC2=C(N=CN2[C@@H]2C[C@H](CO)C=C2)C(NC2CC2)=N1.NC1=NC2=C(N=CN2[C@@H]2C[C@H](CO)C=C2)C(NC2CC2)=N1 |
107.62 |
– |
300 mg twice /day |
| Bortezomib |
CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=CN=CC=N1)B(O)O |
117.23 |
[52] |
1.3 mg/12 hour |
| Metoprolol tartrate |
[H][C@](O)(C(O)=O)[C@@]([H])(O)C(O)=O.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 |
129.23 |
– |
160 mg/day |
| Rifabutin |
CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C)C(O)=C4C(O)=C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C1=C(N=C5C=C(C)C=CN15)C4=C3C2=O |
145.19 |
– |
60 mg/day |
| Ritonavir |
CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O |
163.36 |
[54]–[56]
|
50 to 100 mg twice/day |
| Tetraethylene glycol |
C(COCCOCCOCCO)O |
171.14 |
Clinical trials |
2000 mg/day |
| Adenosine monophosphate |
C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O)N |
178.32 |
– |
500 mg/day |
| Lopinavir |
CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1 |
183.14 |
[55]–[56]
|
800 mg/day |
| Chloroquine phosphate |
OP(O)(O)=O.CCN(CC)CCCC(C)NC1=CC=NC2=CC(Cl)=CC=C12 |
189.35 |
[47] |
500 mg / week |
| Atazanavir |
COC(=O)N[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)[C@@H](O)CN(CC1=CC=C(C=C1)C1=CC=CC=N1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C |
195.57 |
– |
400 mg / day |
| Remdesivir |
CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@](C#N)([C@H](O)[C@@H]1O)C1=CC=C2N1N=CN=C2N)OC1=CC=CC=C1 |
201.13 |
[51] |
200 mg / day |
in nM