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. 2021 Oct 25;45(2):567–572. doi: 10.1007/s10753-021-01567-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A H&E and immunohistochemistry of ACE2 in non-IBD (n = 10), UC (all colon) and CD (ileum and colon) (n = 11) patients. Representative images of non-inflamed and inflamed colonic and ileal mucosal sections. Arrowhead indicating plasma cells. B ACE2 and TMPRSS2 positive cells (%) within lamina propria in inflamed and uninflamed colon of UC vs. non-IBD controls (**p < 0.001 and *** p < 0.0001). C, D Immunofluorescence co-staining of ACE2 (Red), MUM1 (Green), and DAPI (Blue) as nuclear stain within the lamina propria of in inflamed and uninflamed colon of UC vs. non-IBD controls. E Immunofluorescence co-staining of ACE2 (Red), MUM1 (Green) and DAPI (Blue) as nuclear stain within the lamina propria of expression in fatal COVID-19 (SARS-CoV-2 PCR positive) ileum and colon sections; and non-IBD controls. F H&E and immunohistochemistry of ACE2 and TMPRSS2 protein expression in fatal COVID-19 (COVID-19 colon and ileum — n = 4 and 5 mucosal sections respectively). G ACE2 and TMPRSS2 protein weighted histoscore expressions within membrane and cytoplasm of intestinal enterocyte (COVID-19 colon and ileum — n = 4 and 5 mucosal sections respectively and 9 non-IBD colon).

Fig. 2 — A H&E and immunohistochemistry of ACE2 in non-IBD (n = 10), UC (all colon) and CD (ileum and colon) (n = 11) patients. Representative images of non-inflamed and inflamed colonic and ileal mucosal sections. Arrowhead indicating plasma cells. B ACE2 and TMPRSS2 positive cells (%) within lamina propria in inflamed and uninflamed colon of UC vs. non-IBD controls (**p < 0.001 and *** p < 0.0001). C, D Immunofluorescence co-staining of ACE2 (Red), MUM1 (Green), and DAPI (Blue) as nuclear stain within the lamina propria of in inflamed and uninflamed colon of UC vs. non-IBD controls. E Immunofluorescence co-staining of ACE2 (Red), MUM1 (Green) and DAPI (Blue) as nuclear stain within the lamina propria of expression in fatal COVID-19 (SARS-CoV-2 PCR positive) ileum and colon sections; and non-IBD controls. F H&E and immunohistochemistry of ACE2 and TMPRSS2 protein expression in fatal COVID-19 (COVID-19 colon and ileum — n = 4 and 5 mucosal sections respectively). G ACE2 and TMPRSS2 protein weighted histoscore expressions within membrane and cytoplasm of intestinal enterocyte (COVID-19 colon and ileum — n = 4 and 5 mucosal sections respectively and 9 non-IBD colon).