Table 2.
Enrichment of NCF1, NCF2, and NCF4 in KIRC (DAVID). The diagram showed the GO enrichment in cellular component (CC) terms, biological process (BP) terms, and molecular function (MF) terms and bar plot of Kyoto Encyclopedia of Genes and Genomes (KEGG) enriched terms.
| Gene | Category | Gene set | Description | Size | ES | p value | FDR |
|---|---|---|---|---|---|---|---|
| NCF1 | BP | GO:0002250 | Adaptive immune response | 121 | 0.75491 | <0.001 | <0.001 |
| GO:0002449 | Lymphocyte-mediated immunity | 85 | 0.73747 | <0.001 | <0.001 | ||
| GO:0002694 | Regulation of leukocyte activation | 167 | 0.70281 | <0.001 | <0.001 | ||
| GO:0007159 | Leukocyte cell-cell adhesion | 112 | 0.72889 | <0.001 | <0.001 | ||
| GO:0002764 | Immune response-regulating signaling pathway | 159 | 0.70894 | <0.001 | <0.001 | ||
| CC | GO:0001772 | Immunological synapse | 32 | 0.89059 | <0.001 | <0.001 | |
| GO:0042611 | MHC protein complex | 19 | 0.92416 | <0.001 | 0.0016732 | ||
| GO:0098636 | Protein complex involved in cell adhesion | 35 | 0.83931 | <0.001 | 0.0037646 | ||
| GO:0070820 | Tertiary granule | 155 | 0.8063 | <0.001 | 0.0046849 | ||
| GO:0001891 | Phagocytic cup | 21 | 0.8995 | <0.001 | 0.0050195 | ||
| MF | GO:0042287 | MHC protein binding | 24 | 0.923 | <0.001 | <0.001 | |
| GO:0003823 | Antigen binding | 52 | 0.84395 | <0.001 | 0.0033726 | ||
| GO:0019865 | Immunoglobulin binding | 22 | 0.91359 | <0.001 | 0.0036792 | ||
| GO:0035586 | Purinergic receptor activity | 26 | 0.86795 | 0.0023095 | 0.0040471 | ||
| GO:0052813 | Phosphatidylinositol bisphosphate kinase activity | 74 | 0.82566 | <0.001 | 0.0044676 | ||
| KEGG | hsa05150 | Staphylococcus aureus infection | 52 | 0.92179 | <0.001 | <0.001 | |
| hsa05416 | Viral myocarditis | 56 | 0.90004 | <0.001 | <0.001 | ||
| hsa05320 | Autoimmune thyroid disease | 50 | 0.90708 | <0.001 | <0.001 | ||
| hsa05140 | Leishmaniasis | 71 | 0.89 | <0.001 | <0.001 | ||
| hsa04940 | Type I diabetes mellitus | 41 | 0.90434 | <0.001 | <0.001 | ||
| NCF2 | BP | GO:0009595 | Detection of biotic stimulus | 21 | 0.95106 | <0.001 | <0.001 |
| GO:0033108 | Mitochondrial respiratory chain complex assembly | 68 | -0.66273 | <0.001 | <0.001 | ||
| GO:0010257 | NADH dehydrogenase complex assembly | 49 | -0.73433 | <0.001 | <0.001 | ||
| GO:0042116 | Macrophage activation | 78 | 0.8476 | <0.001 | 0.00047859 | ||
| GO:0042107 | Cytokine metabolic process | 106 | 0.848 | <0.001 | 0.0004994 | ||
| CC | GO:0042611 | MHC protein complex | 19 | 0.93646 | <0.001 | <0.001 | |
| GO:0030964 | NADH dehydrogenase complex | 43 | -0.65251 | <0.001 | <0.001 | ||
| GO:0098798 | Mitochondrial protein complex | 213 | -0.5402 | <0.001 | <0.001 | ||
| GO:0001772 | Immunological synapse | 32 | 0.87477 | <0.001 | 0.00058165 | ||
| GO:0070820 | Tertiary granule | 155 | 0.84456 | <0.001 | 0.00087247 | ||
| MF | GO:0038187 | Pattern recognition receptor activity | 20 | 0.94123 | <0.001 | <0.001 | |
| GO:0042287 | MHC protein binding | 24 | 0.91201 | <0.001 | 0.00094517 | ||
| GO:0003823 | Antigen binding | 52 | 0.87062 | <0.001 | 0.00094517 | ||
| GO:0019865 | Immunoglobulin binding | 22 | 0.93547 | <0.001 | 0.0012602 | ||
| GO:0043394 | Proteoglycan binding | 33 | 0.87104 | <0.001 | 0.0040957 | ||
| KEGG | hsa05150 | Staphylococcus aureus infection | 52 | 0.92654 | <0.001 | <0.001 | |
| hsa05140 | Leishmaniasis | 71 | 0.90715 | <0.001 | <0.001 | ||
| hsa05310 | Asthma | 28 | 0.93861 | <0.001 | <0.001 | ||
| hsa05322 | Systemic lupus erythematosus | 122 | 0.86618 | <0.001 | <0.001 | ||
| hsa04640 | Hematopoietic cell lineage | 93 | 0.89299 | <0.001 | <0.001 | ||
| NCF4 | BP | GO:0002250 | Adaptive immune response | 368 | 0.78931 | <0.001 | <0.001 |
| GO:0032609 | Interferon-gamma production | 102 | 0.79916 | <0.001 | <0.001 | ||
| GO:0032613 | Interleukin-10 production | 46 | 0.82482 | <0.001 | <0.001 | ||
| GO:0042110 | T cell activation | 439 | 0.76892 | <0.001 | <0.001 | ||
| GO:0007159 | Leukocyte cell-cell adhesion | 310 | 0.76451 | <0.001 | <0.001 | ||
| CC | GO:0001772 | Immunological synapse | 32 | 0.83629 | <0.001 | <0.001 | |
| GO:0042579 | Microbody | 125 | -0.56583 | <0.001 | <0.001 | ||
| GO:0001891 | Phagocytic cup | 21 | 0.85403 | <0.001 | 0.00053463 | ||
| GO:0070820 | Tertiary granule | 155 | 0.72836 | <0.001 | 0.00080194 | ||
| GO:0042611 | MHC protein complex | 19 | 0.84613 | <0.001 | 0.0016039 | ||
| MF | GO:0019865 | Immunoglobulin binding | 22 | 0.88392 | <0.001 | <0.001 | |
| GO:0016903 | Oxidoreductase activity, acting on the aldehyde or oxo group of donors | 43 | -0.62542 | <0.001 | <0.001 | ||
| GO:0042287 | MHC protein binding | 24 | 0.85887 | <0.001 | 0.0011573 | ||
| GO:0004896 | Cytokine receptor activity | 88 | 0.75566 | <0.001 | 0.001736 | ||
| GO:0019955 | Cytokine binding | 119 | 0.69907 | <0.001 | 0.009982 | ||
| KEGG | hsa05150 | Staphylococcus aureus infection | 52 | 0.88097 | <0.001 | <0.001 | |
| hsa04640 | Hematopoietic cell lineage | 93 | 0.80875 | <0.001 | <0.001 | ||
| hsa05320 | Autoimmune thyroid disease | 50 | 0.84733 | <0.001 | <0.001 | ||
| hsa04672 | Intestinal immune network for IgA production | 45 | 0.83546 | <0.001 | <0.001 | ||
| hsa05140 | Leishmaniasis | 71 | 0.80899 | <0.001 | <0.001 |