Table 3.
Description | Gene markers | NCF1 | NCF2 | NCF4 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
None | Purity | None | Purity | None | Purity | ||||||||
Cor | p | Cor | p | Cor | p | Cor | p | Cor | p | Cor | p | ||
CD8 T cell | CD8A | 0.612 | ∗∗∗ | 0.574 | ∗∗∗ | 0.436 | ∗∗∗ | 0.393 | ∗∗∗ | 0.482 | ∗∗∗ | 0.403 | ∗∗∗ |
CD8B | 0.606 | ∗∗∗ | 0.572 | ∗∗∗ | 0.405 | ∗∗∗ | 0.362 | ∗∗∗ | 0.488 | ∗∗∗ | 0.424 | ∗∗∗ | |
T cell (general) | CD3D | 0.675 | ∗∗∗ | 0.642 | ∗∗∗ | 0.446 | ∗∗∗ | 0.399 | ∗∗∗ | 0.601 | ∗∗∗ | 0.536 | ∗∗∗ |
CD3E | 0.694 | ∗∗∗ | 0.661 | ∗∗∗ | 0.462 | ∗∗∗ | 0.413 | ∗∗∗ | 0.592 | ∗∗∗ | 0.527 | ∗∗∗ | |
CD2 | 0.702 | ∗∗∗ | 0.672 | ∗∗∗ | 0.510 | ∗∗∗ | 0.471 | ∗∗∗ | 0.600 | ∗∗∗ | 0.538 | ∗∗∗ | |
B cell | CD19 | 0.448 | ∗∗∗ | 0.404 | ∗∗∗ | 0.282 | ∗∗∗ | 0.247 | ∗∗∗ | 0.536 | ∗∗∗ | 0.492 | ∗∗∗ |
CD79A | 0.503 | ∗∗∗ | 0.455 | ∗∗∗ | 0.316 | ∗∗∗ | 0.265 | ∗∗∗ | 0.538 | ∗∗∗ | 0.482 | ∗∗∗ | |
Monocyte | CD86 | 0.735 | ∗∗∗ | 0.715 | ∗∗∗ | 0.825 | ∗∗∗ | 0.826 | ∗∗∗ | 0.704 | ∗∗∗ | 0.679 | ∗∗∗ |
CD115 (CSF1R) | 0.684 | ∗∗∗ | 0.665 | ∗∗∗ | 0.685 | ∗∗∗ | 0.677 | ∗∗∗ | 0.738 | ∗∗∗ | 0.720 | ∗∗∗ | |
TAM | CCL2 | 0.129 | ∗∗ | 0.087 | 0.062 | 0.182 | ∗∗∗ | 0.154 | ∗∗ | 0.130 | ∗∗ | 0.077 | 0.100 |
CD68 | 0.545 | ∗∗∗ | 0.528 | ∗∗∗ | 0.613 | ∗∗∗ | 0.618 | ∗∗∗ | 0.484 | ∗∗∗ | 0.493 | ∗∗∗ | |
IL10 | 0.527 | ∗∗∗ | 0.469 | ∗∗∗ | 0.639 | ∗∗∗ | 0.603 | ∗∗∗ | 0.600 | ∗∗∗ | 0.558 | ∗∗∗ | |
M1 macrophage | INOS (ISYNA1) | -0.070 | 0.105 | -0.113 | ∗ | -0.198 | ∗∗∗ | -0.238 | ∗∗∗ | 0.068 | 0.116 | 0.023 | 0.622 |
IRF5 | 0.524 | ∗∗∗ | 0.522 | ∗∗∗ | 0.442 | ∗∗∗ | 0.463 | ∗∗∗ | 0.406 | ∗∗∗ | 0.411 | ∗∗∗ | |
cox2 (PTGS2) | -0.015 | 0.733 | -0.057 | 0.219 | 0.108 | ∗ | 0.089 | 0.056 | 0.163 | ∗∗∗ | 0.117 | ∗ | |
M2 macrophage | CD163 | 0.483 | ∗∗∗ | 0.458 | ∗∗∗ | 0.671 | ∗∗∗ | 0.664 | ∗∗∗ | 0.567 | ∗∗∗ | 0.551 | ∗∗∗ |
VSIG4 | 0.597 | ∗∗∗ | 0.578 | ∗∗∗ | 0.636 | ∗∗∗ | 0.624 | ∗∗∗ | 0.703 | ∗∗∗ | 0.686 | ∗∗∗ | |
MS4A4A | 0.530 | ∗∗∗ | 0.496 | ∗∗∗ | 0.698 | ∗∗∗ | 0.693 | ∗∗∗ | 0.646 | ∗∗∗ | 0.619 | ∗∗∗ | |
Neutrophils | CD66b (CEACAM8) | 0.039 | 0.374 | 0.045 | 0.335 | 0.113 | ∗∗ | 0.136 | ∗∗ | 0.074 | 0.087 | 0.105 | ∗ |
CD11b (ITGAM) | 0.711 | ∗∗∗ | 0.690 | ∗∗∗ | 0.780 | ∗∗∗ | 0.767 | ∗∗∗ | 0.657 | ∗∗∗ | 0.637 | ∗∗∗ | |
CCR7 | 0.540 | ∗∗∗ | 0.496 | ∗∗∗ | 0.463 | ∗∗∗ | 0.429 | ∗∗∗ | 0.579 | ∗∗∗ | 0.540 | ∗∗∗ | |
Natural killer cell | KIR2DL1 | 0.125 | ∗∗ | 0.108 | ∗ | 0.102 | ∗ | 0.053 | 0.260 | 0.096 | ∗ | 0.033 | 0.481 |
KIR2DL3 | 0.134 | ∗∗ | 0.152 | ∗∗ | 0.131 | ∗∗ | 0.118 | ∗ | 0.126 | ∗∗ | 0.110 | ∗ | |
KIR2DL4 | 0.273 | ∗∗∗ | 0.260 | ∗∗∗ | 0.169 | ∗∗∗ | 0.123 | ∗∗ | 0.282 | ∗∗∗ | 0.239 | ∗∗∗ | |
KIR2DS4 | 0.075 | 0.082 | 0.063 | 0.175 | 0.038 | 0.386 | -0.005 | 0.914 | 0.093 | ∗ | 0.072 | 0.120 | |
KIR3DL1 | 0.121 | ∗∗ | 0.144 | ∗∗ | 0.131 | ∗∗ | 0.116 | ∗ | 0.088 | ∗ | 0.075 | 0.107 | |
KIR3DL2 | 0.184 | ∗∗∗ | 0.174 | ∗∗∗ | 0.110 | ∗ | 0.091 | 0.051 | 0.165 | ∗∗∗ | 0.146 | ∗∗ | |
KIR3DL3 | 0.130 | ∗∗ | 0.098 | ∗ | 0.073 | 0.092 | 0.056 | 0.231 | 0.144 | ∗∗ | 0.122 | ∗∗ | |
Dendritic cell | HLA-DPA1 | 0.702 | ∗∗∗ | 0.672 | ∗∗∗ | 0.697 | ∗∗∗ | 0.680 | ∗∗∗ | 0.576 | ∗∗∗ | 0.522 | ∗∗∗ |
HLA-DPB1 | 0.763 | ∗∗∗ | 0.749 | ∗∗∗ | 0.686 | ∗∗∗ | 0.667 | ∗∗∗ | 0.640 | ∗∗∗ | 0.609 | ∗∗∗ | |
HLA-DQB1 | 0.487 | ∗∗∗ | 0.442 | ∗∗∗ | 0.419 | ∗∗∗ | 0.376 | ∗∗∗ | 0.402 | ∗∗∗ | 0.341 | ∗∗∗ | |
HLA-DRA | 0.731 | ∗∗∗ | 0.714 | ∗∗∗ | 0.750 | ∗∗∗ | 0.741 | ∗∗∗ | 0.612 | ∗∗∗ | 0.583 | ∗∗∗ | |
BDCA-1 (CD1C) | 0.395 | ∗∗∗ | 0.345 | ∗∗∗ | 0.460 | ∗∗∗ | 0.419 | ∗∗∗ | 0.429 | ∗∗∗ | 0.379 | ∗∗∗ | |
BDCA-4 (NRP1) | -0.001 | 0.982 | -0.064 | 0.167 | 0.212 | ∗∗∗ | 0.166 | ∗∗∗ | 0.050 | 0.247 | -0.015 | 0.756 | |
CD11c (ITGAX) | 0.655 | ∗∗∗ | 0.629 | ∗∗∗ | 0.676 | ∗∗∗ | 0.670 | ∗∗∗ | 0.645 | ∗∗∗ | 0.639 | ∗∗∗ | |
Th1 | T-bet (TBX21) | 0.455 | ∗∗∗ | 0.434 | ∗∗∗ | 0.297 | ∗∗∗ | 0.261 | ∗∗∗ | 0.426 | ∗∗∗ | 0.383 | ∗∗∗ |
STAT4 | 0.454 | ∗∗∗ | 0.404 | ∗∗∗ | 0.373 | ∗∗∗ | 0.342 | ∗∗∗ | 0.523 | ∗∗∗ | 0.465 | ∗∗∗ | |
IFN-γ (IFNG) | 0.592 | ∗∗∗ | 0.553 | ∗∗∗ | 0.410 | ∗∗∗ | 0.365 | ∗∗∗ | 0.453 | ∗∗∗ | 0.382 | ∗∗∗ | |
TNF-α (TNF) | 0.478 | ∗∗∗ | 0.475 | ∗∗∗ | 0.388 | ∗∗∗ | 0.384 | ∗∗∗ | 0.462 | ∗∗∗ | 0.437 | ∗∗∗ | |
STAT1 | 0.588 | ∗∗∗ | 0.537 | ∗∗∗ | 0.633 | ∗∗∗ | 0.605 | ∗∗∗ | 0.428 | ∗∗∗ | 0.352 | ∗∗∗ | |
Th2 | GATA3 | 0.212 | ∗∗∗ | 0.234 | ∗∗∗ | 0.133 | ∗∗ | 0.118 | ∗ | 0.222 | ∗∗∗ | 0.188 | ∗∗∗ |
STAT6 | 0.150 | ∗∗∗ | 0.167 | ∗∗∗ | 0.189 | ∗∗∗ | 0.206 | ∗∗∗ | 0.099 | ∗ | 0.138 | ∗∗ | |
STAT5A | 0.629 | ∗∗∗ | 0.614 | ∗∗∗ | 0.598 | ∗∗∗ | 0.583 | ∗∗∗ | 0.535 | ∗∗∗ | 0.495 | ∗∗∗ | |
IL13 | 0.053 | 0.219 | 0.038 | 0.420 | -0.063 | 0.145 | -0.061 | 0.194 | 0.173 | ∗∗∗ | 0.165 | ∗∗∗ | |
Tfh | BCL6 | -0.029 | 0.500 | -0.034 | 0.465 | 0.029 | 0.499 | 0.028 | 0.544 | 0.091 | ∗ | 0.098 | ∗ |