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p-STAT3 activation downregulates P53 expression to rescue bavachin-induced ferroptosis in osteosarcoma (OS) cells. (a, b) Western blotting shows the relative levels of p-STAT3, STAT3, P53, and GPX4 protein expression. (c) p-STAT3 activation restores bavachin-induced GSH depletion. (d, e) p-STAT3 activation reduces bavachin-induced ROS and MDA accumulation. (f) p-STAT3 activation rescues bavachin-induced ferroptosis in OS cells. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.
