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. 2021 Oct 18;2021:3687700. doi: 10.1155/2021/3687700

Table 1.

The effect of paclitaxel nanoformulation against different types of cancer.

Paclitaxel nanoformulation Target tissue/type of cancer Mode of delivery Reference
Nanoformulated paclitaxel and AZD9291 Lung cancer AZD9291-loaded disulfide cross-linking micelles (DCMs) [94]
Low-dose nanoparticle albumin-bound paclitaxel (nab-PTX) HER2-negative metastatic breast cancer Albumin nanoparticles [95, 96]
Nab-paclitaxel–gemcitabine combination Pancreatic cancer Albumin nanoparticles [97]
Milk-derived exosomal formulation of PAC (ExoPAC) Lung cancer Exosomes [98]
PTX-GemC12-LNC formulation Brain tumour (glioblastoma) Liquid nanoparticle [99]
Paclitaxel-loaded PCL-TPGS nanoparticles:
PTX-loaded poly(caprolactone)–alpha-tocopheryl polyethylene glycol 1000 succinate (PCL-TPGS) NPs
Breast cancer PCL-TPGS copolymer [100]
Paclitaxel-loaded poly(glycolide-co-ε-caprolactone)-b-D-α-tocopheryl polyethylene glycol 2000 succinate nanoparticles (PTX-loaded (PGA-co-PCL)-b-TPGS2k Lung cancer Amphiphilic copolymer (PGA-co-PCL)-b-TPGS2k [101]
Paclitaxel and superparamagnetic iron oxide-loaded PEGylated poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (PTX/SPIO-NPs) Glioblastoma Superparamagnetic iron oxide-PEGylated poly(lactic-co-glycolic acid)-based nanoparticles [102]
PTX micelles Pulmonary carcinoma Poly(ethylene glycol)-poly(3-caprolactone) copolymers (MPEG-PCL micelles) [103]
Paclitaxel-loaded vitamin E-TPGS nanoparticles Lung cancer
Breast cancer
Colorectal cancer
Brain cancer
Prostate cancer
TPGS nanoparticles [75, 100, 104107]
PTX nanomicelles using poly(styrene-co-maleic acid) (SMA); SMA-PTX micelles Murine orthotopic colon cancer model Poly(styrene-co-maleic acid) [108]
Lumbrokinase/paclitaxel/poly(ethylene glycol)-b-(poly(ethylenediamine l-glutamate)-g-poly(ε-benzyoxycarbonyl-l-lysine)-r-poly(l-lysine)) LK/PTX/PEG-b-(PELG-g-(PZLL-r-PLL)) Bladder cancer Poly(ethylene glycol)-b-(poly(ethylenediamine l-glutamate)-g-poly(ε-benzyoxycarbonyl-l-lysine)-r-poly(l-lysine)) [109]
Paclitaxel dimer-methoxypoly(ethylene glycol)2K-block-poly(D,L-lactide)2K (PTX dimer)/PEG-PDLLA formulations Cervical cancer Methoxypoly(ethylene glycol)2K-block-poly(D,L-lactide)2K (PEG-PDLLA) micelles [110]
PTX-loaded redox-sensitive HSV nanoparticles Lung cancer Hyaluronic acid-disulfide-vitamin E succinate (HA-SS-VES, HSV) conjugate [111]
Thermostable RNA-PTX nanoparticles (4WJ-X-24 PTX nanoparticles) Breast cancer RNA nanoparticles [112]