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Plasma levels of oxidative stress markers at baseline and after 3 months of treatment in the placebo and melatonin groups. (a) Lipoperoxides (malonaldehyde + 4 hydroxyalkenes), (b) nitric oxide metabolites (nitrates and nitrites), (c) carbonyl groups in proteins, and (d) catalase enzyme activity. Data of the mean ± standard error and a p < 0.05 are shown.
