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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Biomaterials. 2021 Sep 1;277:121114. doi: 10.1016/j.biomaterials.2021.121114

Figure 2.

Figure 2.

Schematic of PBA- mediated adenosine sequestration. a) 3-(Acrylamido)phenylboronic acid (PBA) contains a boronic acid moiety (circled) that forms a dynamic covalent complex of cyclic boronate ester with cis- diol- bearing adenosine. b) A PBA-conjugated biomaterial sequesters surge of extracellular adenosine at the fracture site after injury and sustains elevated and localized adenosine levels to accelerate fracture repair. c) 3D reconstructions and corresponding radiographs of the fractured tibiae at 21 d post-injury treated with various biomaterial patches. White boxes enclose the callus regions. Scale bars: 1 mm. d) Bone volume ratio (BV/TV) of calluses quantified from figure (c) at 21 d post-fracture. Reprinted with permission from [17].