Fig. 8.

Cartoon representation of (A) WT and (B-L) mutant FP-2 with the distribution of the averaged BC hubs unique to each mutant protein with respect to WT (skyblue spheres). WT averaged BC hubs are in salmon color. Catalytic thiol (of C285) is marked with a black stick if it is identified as a new averaged BC hub; otherwise is red. The other common hub, residue S289, is also labelled. ART-linked mutations are represented as firebrick spheres and the rest of the mutations are in grey spheres. Catalytic residues are shown in orange if they are not hubs. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)