Fig. 9.

Cartoon representation of WT and T343P mutant proteins with their averaged BC hubs. (A) WT with the distribution of the averaged BC hubs depicted as salmon colored spheres. (B) T343P with its unique hubs (skyblue) and the ones common to the WT hubs (salmon). (C) and (D) show the allosteric communication path formed by four unique hubs originating from T343P and going to the catalytic site, passing through the interface of three pockets.