Fig. 10.

Cartoon representation of (A) WT and (B-L) mutant FP-2, with the distribution of the averaged DC hubs unique to each mutant protein with respect to WT (skyblue spheres). WT averaged DC hubs are in salmon color. ART resistance-linked mutations are depicted as firebrick spheres and the rest of the mutations are in grey spheres. Catalytic residues are shown in orange if they are not hubs. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)