Fig. 12.

Cartoon representation of T343P mutant protein with its averaged EC hubs. Unique hubs of T343P mutant protein are in skyblue, and the ones common with the WT hubs are in salmon. The allosteric communication path is formed by five unique EC hubs originating from Pocket 5 (green) and going to the catalytic site, interacting with H417. Catalytic triad residues are depicted in orange. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)