Fig. 13.

Residue contact analysis heatmaps showing the interaction changes around (A) the mutations and (B) catalytic triad residues (C285, H417 and N447). Dashed boxes in panel A show mutations causing significant interaction changes between the mutated residue and its surrounding contacting residues with respect to the native network in WT. Color code represents the contact frequency where 0 = no contact and 1.0 = strong contact between target and contacting residues.