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Allosteric per-residue free energy changes associated with the missense mutations occurring on the catalytic domains of FP-2. The resulting destabilization (ΔG greater than 0 kcal/mol) and stabilization (ΔG < 0 kcal/mol) effects on the proteins are shown in blue and red. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
