Table 2.

Dynamic inter-residue contact analysis around persistent hubs showed significant changes (new/enhanced or lost/reduced) in interactions with respect to the WT. Neighbor residues are indicated in bold and are underlined.

Protein	New/Increased	Lost/Reduced
M245I	I389-S293, I391-M420, S293-I389, S390-A418, Y441-K439	I389-L379, F288-G292, S289-A287, S293-Q297
E248D	I389-S293, I391-M420, S293-I389, S296-G387, S390-A418, Y441-K439	I389-L379, F288-G292, S289-A287
E249A	I389-S293, I391-M420, I445-V422, S289-S448, S296-G387
K255R	I389-S293, S289-S448, I445-M420	F288-G292, S284-C323, W286-C325
N257E	I389-S293, I391-S289, S284-S351, S290-M335, I445-M420, Y441-K439	I389-L379, M420-S293, S296-V273, S390-M420, W286-S284
T343P	I389-S293, I445-M420, S289-S293, S296-W267, Y441-K439	I389-L379, S284-W286, W286-C325
D345G	I389-S293, I445-M420, S296-G387, Y441-K439	L421-L383, P388-V273
A353T	I389-S293, I445-M420, S289-S448, Y441-K439, W286-S284	F288-G292, P388-V273
V393I	I389-S293, I445-M420, S289-S448, S296-W267, Y441-K439	L421-L383, W286-C325
A400P	I389-S293, I391-M420, S289-S448, S293-S289, Y441-K439
Q414E	I389-S293, I391-M420, I445-M420, S296-W267, Y441-K439	W286-C325, S296-G387