Table 3.
Intergroup differences of vertex-wise SBFC of the right posterior hippocampal subfields in rTLE vs. HCs.
| ROI | Region | HPC (vertices) | Cluster | Peak | Coordinates MNI | t | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Size (mm2) | Vertex | x | y | z | ||||||
| rCA3 | rTLE < HC | L | DLPFC | 67 (41) 68 (33) 73 (4) 97 (2) | 808 | 218 | −35 | 21 | 49 | −5.54 |
| R | DLPFC | 70 (13) 68 (5) 98 (1) | 244 | 8,656 | 18 | 32 | 51 | −4.45 | ||
| LTC | 132 (18) 176 (9) 177 (8) | 374 | 3,956 | 63 | −17 | −21 | −5.01 | |||
| IPC | 150 (34) 151 (6) | 409 | 2,358 | 50 | −63 | 27 | −4.47 | |||
| PVC | 1 (34) 4 (12) | 558 | 10,007 | 21 | −101 | −12 | −4.56 | |||
| rEC | rTLE > HC | R | ACC | 60 (21) 57 (14) | 259 | 4,536 | 8 | 7 | 50 | 4.59 |
Statistically significant differences in SBFC were defined as vertex p < 0.001 and cluster size p < 0.05 (p < 0.025 for each hemisphere), Monte Carlo simulation-corrected after correcting for age, sex, education, and head motion. MNI, Montreal Neurological Institute; HCP, Human Connectome Project; SBFC, surface-based functional connectivity; rTLE, right temporal lobe epilepsy; HCs, healthy controls; Sub, subiculum; DLPFC, dorsolateral prefrontal cortex; LTC, Lateral temporal cortex; IPC, inferior parietal cortex; PVC, posterior visual cortex; EC, entorhinal cortex; ACC, anterior cingulate cortex.