TABLE 1.

Researches on the pyroptosis in diabetic encephalopathy.

Diseases	The mechanism that triggering pyroptosis	Inflammasomes	References
Diabetic cerebral I/R model	Activated and induced microglial pyroptosis	NLRC4	Wang L. Q. et al., 2021
Cognitive disorder in offspring of diabetes	Aggregation of macrophages caused by the aggregation of chemotactic proteins	NLRP3	Liang et al., 2019
Diabetic cognitive impairment	P2 × 7R/NLRP1/caspase-1	NLRP1	Jing et al., 2021
Diabetic depression	ROS overproduction	NLRP3	Li et al., 2020
Diabetic brain damage	miR-214-3p/caspase-1/ATG12 axis	NLRP3	Che et al., 2020
Diabetic cerebral ischemia	Activation of autophagy	NLRP3	Tu et al., 2019
Diabetic ischemic stroke	Activation of NLRP3 inflammasome	NLRP3	Hong et al., 2018
Diabetic brain injury	Pannexin 1 mediated the activation of NLRP1 inflammasome	NLRP1	Meng et al., 2014