Figure 4 (IL-1B).

Meta-analysis of studies analyzing the association between IL-1B polymorphisms and H. pylori eradication treatment failure. Compared to the TC or TT genotype (higher IL-1B expression, more potent acid suppression), the CC genotype was associated with a 1.72-fold significantly higher likelihood of eradication failure (moderate, statistically significant heterogeneity I² 51.5%, P=0.05). Note, this analysis excludes the two studies by Matsuo et al. and Ishida et al., and includes only the IL-1B-31 genetic polymorphism from the Hong et al. study to avoid potential duplicates (see text for full details and supplemental material for additional IL-1B analyses)