Table 2.
Diagnostic performance of MPI, pooled sensitivity, specificity, diagnostic OR and area under the receiver operating characteristic curve of all AC, CTAC, RAC, and NAC in diagnosing CAD at a patient level and detecting LAD, LCX, and RCA stenosis.
| Sensitivity | P -value | Specificity | P -value | DOR | P -value | AUC | ||
|---|---|---|---|---|---|---|---|---|
| PT | All AC | 0.82 (0.76–0.87) | 0.29 | 0.78 (0.71–0.83) | <0.001 | 16(11–24) | 0.015 | 0.87 (0.84–0.89) |
| CTAC | 0.77 (0.66–0.85) | 0.18 | 0.82 (0.75–0.86) | <0.001 | 15(10–22) | 0.08 | 0.86 (0.83–0.89) | |
| RAC | 0.85 (0.82–0.88) | 0.38 | 0.74 (0.62–0.83) | 0.12 | 16(8–33) | 0.08 | 0.87 (0.84–0.90) | |
| All NAC | 0.86 (0.81–0.90) | NA | 0.58 (0.48–0.67) | NA | 8(6–12) | NA | 0.82 (0.78–0.85) | |
| LAD | All AC | 0.76 (0.67–0.82) | 0.42 | 0.81 (0.75–0.86) | 0.50 | 13(9–20) | 0.15 | 0.86 (0.82–0.88) |
| CTAC | 0.77 (0.64–0.87) | 0.64 | 0.82 (0.71–0.89) | 0.79 | 15(9–26) | 0.41 | 0.87 (0.83–0.89) | |
| RAC | 0.73 (0.64–0.81) | 0.36 | 0.80 (0.76–0.84) | 0.41 | 11(6–21) | 0.25 | 0.84 (0.81–0.87) | |
| NAC | 0.70 (0.63–0.76) | NA | 0.79 (0.70–0.85) | NA | 9(6–13) | NA | 0.80 (0.76–0.83) | |
| LCX | All AC | 0.64 (0.52–0.75) | 0.97 | 0.91 (0.83–0.95) | 0.40 | 18(10–32) | 0.33 | 0.85 (0.82–0.88) |
| CTAC | 0.65 (0.45–0.81) | 0.34 | 0.89 (0.76–0.96) | 0.61 | 15(7–33) | 0.34 | 0.85 (0.82–0.88) | |
| RAC | 0.64 (0.53–.075) | 0.97 | 0.92 (0.83–0.96) | 0.41 | 20(8–52) | 0.33 | 0.84 (0.80–0.87) | |
| NAC | 0.64 (0.52–0.75) | NA | 0.86 (0.76–0.92) | NA | 11(6–20) | NA | 0.82 (0.78–0.85) | |
| RCA | All AC | 0.73 (0.63–0.80) | 0.10 | 0.87 (0.82–0.91) | <0.001 | 18(11–29) | 0.003 | 0.88 (0.85–0.91) |
| CTAC | 0.71 (0.54–0.84) | 0.12 | 0.88 (0.79–0.93) | 0.003 | 18(9–36) | 0.23 | 0.89 (0.85–0.91) | |
| RAC | 0.74 (0.67–0.81) | 0.65 | 0.87 (0.82–0.90) | <0.001 | 19(10–37) | 0.003 | 0.87 (0.85–0.91) | |
| NAC | 0.82 (0.73–0.88) | NA | 0.61 (0.51–0.71) | NA | 7(5–10) | NA | 0.79 (0.75–0.82) |
The p-values of CTAC and RAC were compared with the NAC data in the CTAC or RCA studies, separately.
Data in parentheses are 95% CIs.
AC, attenuation correction; AUC, area under receiver operating characteristic curve; CTAC, computed tomography AC; DOR, diagnostic odds ratio; LAD, left anterior descending artery; LCX, left circumflex artery; NA, not available; NAC, non-AC; PT, patient; RAC, radionuclide AC; RCA, right coronary artery.