Skip to main content
. 2021 Oct 12;9:717624. doi: 10.3389/fcell.2021.717624

TABLE 1.

Surface markers and pre-lineages expression profile of dental pulp stem cells (DPSCs).

Marker Protein name Expression strength References
MSCs surface markers
Stro-1 Stro-1 antigen remains unidentified +++ Shi et al., 2005; Jo et al., 2007; Liu et al., 2009; Atari et al., 2011; Huang et al., 2014
CD9 (TSPAN29) Cell growth-inhibiting gene 2 protein ++ Kawanabe et al., 2012; Niehage et al., 2016
CD13 (ANPEP) Alanyl aminopeptidase ++ Huang et al., 2009; Atari et al., 2011; Kawanabe et al., 2012
CD29 (ITGB1) Integrin beta 1 ++ Huang et al., 2009; Kawanabe et al., 2012; Niehage et al., 2016; Mendi et al., 2017
CD39 (Entpd1) Lymphoid cell activation antigen + Niehage et al., 2016
CD44 CD44 antigen +++ Shi et al., 2005; Huang et al., 2009; Kawanabe et al., 2012; Niehage et al., 2016; Mendi et al., 2017
CD49a, b, c, d, e (ITGA1,2,3,4,5) Integrin alpha-1,2,3,4,5 ++ Ferro et al., 2012a; Kawanabe et al., 2012
CD51 (ITGAV) Integrin alpha V + Kawanabe et al., 2012
CD73 (NT5E) 5’-nucleotidase +++ Huang et al., 2009; Kawanabe et al., 2012; Ponnaiyan et al., 2012; Niehage et al., 2016; Mendi et al., 2017
CD90 (Thy-1) Thy-1 membrane glycoprotein +++ Huang et al., 2009; Kawanabe et al., 2012; Ponnaiyan et al., 2012; Niehage et al., 2016; Mendi et al., 2017
CD105 (END) Endoglin ++ Huang et al., 2009; Ferro et al., 2012a; Kawanabe et al., 2012; Ponnaiyan et al., 2012; Niehage et al., 2016
Cd117 (c-Kit) Mast/stem cell growth factor receptor Kit + Yang et al., 2009; Ishkitiev et al., 2012; Kawashima, 2012
CD146 (MUC18) Melanoma Cell Adhesion Molecule +++ Shi et al., 2005; Huang et al., 2009, 2014; Niehage et al., 2016
CD151 (TSPAN24) Platelet-endothelial tetraspan antigen 3 +++ Niehage et al., 2016
CD166 (ALCAM) Activated Leukocyte Cell Adhesion Molecule +++ Kawanabe et al., 2012; Ponnaiyan et al., 2012; Niehage et al., 2016
Other surface markers
CD59 CD59 glycoprotein + Huang et al., 2009; Ferro et al., 2012a
ITA10 (ITGA10) Integrin alpha 10 ++ Liu J. et al., 2011; Niehage et al., 2016
ITA8 (ITGA8) Integrin alpha 8 + Liu J. et al., 2011; Niehage et al., 2016
CD325 (CDH2) Cadherin-2 ++ Niehage et al., 2016
MFGM Lactadherin + Niehage et al., 2016
Embryonic stem cells markers
OCT4 (POU5F1) POU domain, class 5, transcription factor 1 +++ Kerkis et al., 2006; Atari et al., 2011; Liu L. et al., 2011; Ishkitiev et al., 2012; Kawanabe et al., 2012; Ponnaiyan et al., 2012; Huang et al., 2014; Wu et al., 2015; Ballini et al., 2019
Nanog Homeobox protein NANOG +++ Kerkis et al., 2006; Atari et al., 2011; Liu L. et al., 2011; Ishkitiev et al., 2012; Kawanabe et al., 2012; Ponnaiyan et al., 2012; Huang et al., 2014; Ballini et al., 2019
KLF4 Krueppel-like factor 4 + Ballini et al., 2019
c-Myc MYC proto-oncogene, BHLH transcription facto + Liu L. et al., 2011; Ballini et al., 2019
Sox2 Transcription factor SOX-2 ++ Govindasamy et al., 2010; Atari et al., 2011; Kawanabe et al., 2012; Ballini et al., 2019
Sox1 Transcription factor SOX-1 ++ Atari et al., 2012; Ferro et al., 2012a; Tan and Dai, 2017
CD9 Tetraspanin receptor +++ Lindroos et al., 2008; Ponnaiyan et al., 2012
CD13 Aminopeptidase N ++ Ponnaiyan et al., 2012; Akpinar et al., 2014
SSEA4 Stage specific embryonic antigen 4 ++ Kerkis et al., 2006; Atari et al., 2011; Ferro et al., 2012a; Kawanabe et al., 2012; Ponnaiyan et al., 2012
SSEA3 Stage specific embryonic antigen 3 + Kerkis et al., 2006; Ferro et al., 2012a; Kawanabe et al., 2012
SSEA1 Stage specific embryonic antigen 1 + Kawanabe et al., 2012
REX1 (ZFP42) Zinc finger protein 42 homolog, Zfp-42 ++ Kawanabe et al., 2012
TERT Telomerase reverse transcriptase + Huang et al., 2009
TRA-1-60 TRA-1-60 antigens + Kerkis et al., 2006; Atari et al., 2012
TRA-1-81 TRA-1-81 antigens + Kerkis et al., 2006
MixL1 MIX1 homeobox-like protein 1 + Atari et al., 2012
GATA4 GATA binding protein 4 + Atari et al., 2012
GATA6 GATA binding protein 6 + Atari et al., 2012
Immune markers
HLA-ABC MHC class I antigen + Ponnaiyan et al., 2012
Osteo/odontogenic markers
ALP Alkaline phosphatase +++ Shi et al., 2005; Huang et al., 2009; Yildirim et al., 2016; Ching et al., 2017
BSP Bone Sialoprotein 2 + Sonoyama et al., 2008; Huang et al., 2009
OCN Osteocalcin +++ Shi et al., 2005; Sonoyama et al., 2008; Huang et al., 2009; Ching et al., 2017
OPN Osteopontin ++ Shi et al., 2005
MEPE Matrix extracellular phosphoglycoprotein +++ Sonoyama et al., 2008; Huang et al., 2009; Ching et al., 2017
Runx2 (OSF-2) Osteoblast-specific transcription factor 2 + Huang et al., 2009; Yildirim et al., 2016
Scleraxis Tendon specific transcription factor + Shi et al., 2005; Huang et al., 2009
Angiogenic markers
Endostatin (COL18A1) Collagen Type XVIII Alpha 1 Chain ++ Huang et al., 2009; Bronckaers et al., 2013; Hilkens et al., 2014
VEGF Vascular endothelial growth factor + Tran-Hung et al., 2008; Bronckaers et al., 2013; Hilkens et al., 2014; Yu et al., 2016
ANGPT1 Angiopoietin-1 + Bronckaers et al., 2013; Hilkens et al., 2014; Yu et al., 2016
IFGBP3 Insulin-like growth factor binding protein 3 + Bronckaers et al., 2013; Hilkens et al., 2014; Yu et al., 2016
PTX3 Pentraxin-3 + Bronckaers et al., 2013; Hilkens et al., 2014; Bakopoulou et al., 2015
PAI-1 Plasminogen activator inhibitor 1 +++ Bronckaers et al., 2013; Hilkens et al., 2014; Yu et al., 2016
TIMP1 Tissue inhibitor of matrix metalloproteinase 1 +++ Bronckaers et al., 2013; Hilkens et al., 2014; Bakopoulou et al., 2015; Yu et al., 2016
PDGF Platelet-derived growth factor + Tran-Hung et al., 2008
Growth factors receptors
TGFβRII Transforming growth factor beta receptor 2 + Huang et al., 2009; Karaoz et al., 2011
FGFR3 Fibroblast growth factor receptor 3 +++ Huang et al., 2009
EGFR Epidermal growth factor receptor + Niehage et al., 2016
Flt-1 (VEGFR1) Vascular endothelial growth factor receptor 1 + Huang et al., 2009
FGFR1 Fibroblast growth factor receptor 1 +++ Huang et al., 2009
CD271 (NGFR) Low-affinity nerve growth factor receptor + Nakashima et al., 2009; Mikami et al., 2011
Neuronal markers
Nes Nestin + Huang et al., 2009; Martens et al., 2014; Yildirim et al., 2016
bFGF (FGF2) Fibroblast growth factor 2 ++ Tran-Hung et al., 2008; Huang et al., 2009
BDNF Brain-derived neurotrophic factor ++ Atari et al., 2012; de Almeida et al., 2014
NFM (NEF3) Neurofilament medium polypeptide + Huang et al., 2009; Martens et al., 2014; Yu et al., 2016
GDNF Glial cell derived neurotrophic factor + Huang et al., 2009; Martens et al., 2014; Yu et al., 2016
NGF Nerve growth factor + Huang et al., 2009; Martens et al., 2014; Yu et al., 2016
NCAM2 Neural Cell Adhesion Molecule 2 + Martens et al., 2014; Niehage et al., 2016; Yu et al., 2016
Slug Neural crest transcription factor slug ++ Huang et al., 2009
TUBB3 Tubulin beta 3 Class III ++ Huang et al., 2009