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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: FEBS Lett. 2021 Sep 19;595(20):2558–2569. doi: 10.1002/1873-3468.14191

Figure 5. SNX6 modulates tumor-T-cell response.

Figure 5.

(A) UMSCC1 cells was transfected with control or SNX6 siRNA, and then co-cultured with activated Jurkat T-cells. The production of IL-2 by Jurkat T-cells was detected by IL-2 ELISA Kits. (B) Nuclear-restricted RFP-expressing MDA-MB-231 cells were transfected with control or SNX6 siRNA and then co-cultured with activated T-cells in the presence of caspase 3/7 substrate (Essen Bioscience). RFP and green fluorescent (NucView 488 Caspase 3/7 substrate) signals were then monitored. The green-fluorescent cells were counted as dead cells. (C) Quantification of dead cells in control or SNX6-knockdown MDA-MB-231 cells co-cultured with activated T-cells.