Acute effect of AgNP exposure on BALF (A) total protein, (B) albumin, (C) total cells, (D) macrophages and (E) neutrophils from healthy and MetS mice and modulation by lipid interventions. Thirty minutes prior to oropharyngeal aspiration of pharmaceutical grade sterile water (control) or AgNPs (50 μg) in sterile water, mice were i.p. injected with 1 μg of 14-HDHA, 17-HDHA, or 18-HEPE or vehicle (250 μl of sterile saline). Values are expressed as mean ± SEM (n = 6–8/group). * denotes significant differences due to AgNP exposure comparing to model-matched control receiving the same treatment, # denotes significant differences between healthy and MetS mouse models receiving the same treatments and exposure, $ denotes significant differences due to lipid interventions comparing to groups not receiving treatment but the same exposure (p < 0.05).