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. Author manuscript; available in PMC: 2022 Nov 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2021 Sep 30;431:115730. doi: 10.1016/j.taap.2021.115730

Fig. 5.

Fig. 5.

Alterations in BALF cytokine/chemokines proteins 24 h after AgNP exposure in healthy and MetS mice and the influence of lipid interventions. Proteins levels of (A) MIP-2, (B) MCP-1, (C) IL-6, and (D) CXCL1 were examined in BALF to determine disease-related differences in AgNP-induced inflammatory response and the influence of lipid treatments. Thirty minutes prior to oropharyngeal aspiration of pharmaceutical grade sterile water (control) or AgNPs (50 μg) in sterile water, mice were i.p. injected with 1μg 14-HDHA, 17-HDHA, or 18-HEPE or vehicle (250 μl of sterile saline). Values are expressed as mean ± SEM (n = 6–8/group). * denotes significant differences due to AgNP exposure comparing to model-matched control receiving the same treatment, # denotes significant differences between healthy and MetS mouse models receiving the same treatments and exposure, $ denotes significant differences due to lipid interventions comparing to groups not receiving treatment but the same exposure (p < 0.05).