Skip to main content
. Author manuscript; available in PMC: 2022 Nov 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2021 Sep 30;431:115730. doi: 10.1016/j.taap.2021.115730

Fig. 6.

Fig. 6.

Alterations in genes involved in lipid metabolism 24 h following AgNP exposure in lung tissue from healthy and MetS mice and the influence of lipid interventions. (A) arachidonate-5 lipoxygenase (ALOX-5), and (B) arachidonate 15-lipoxygenase (ALOX-15) were evaluated in lung tissue. Thirty minutes prior to oropharyngeal aspiration of pharmaceutical grade sterile water (control) or AgNPs (50 μg) in sterile water, mice were i.p. injected with 1μg 14-HDHA, 17-HDHA, or 18-HEPE or vehicle (250 μl of sterile saline). Values are expressed as mean ± SEM (n = 6–8/group) fold change compared with control. * denotes significant differences due to AgNP exposure comparing to model-matched control receiving the same treatment, # denotes significant differences between healthy and MetS mouse models receiving the same treatments and exposure, $ denotes significant differences due to lipid interventions comparing to groups not receiving treatment but the same exposure (p < 0.05).