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. Author manuscript; available in PMC: 2022 Nov 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2021 Sep 30;431:115730. doi: 10.1016/j.taap.2021.115730

Fig. 8.

Fig. 8.

Alterations in pulmonary resolution receptors 24 h following AgNP exposure in healthy and MetS mouse models. AgNP-induced alterations in the gene expression of (A) leucine-rich repeat-containing G-protein coupled receptor 6 (Lgr6), (B) Chemokine like receptor 1 (ChemR23), and (C) G protein-coupled receptor 18 (GPCR18) were evaluated in lung tissue. Alterations in receptors associated with lipid mediator of inflammatory resolution were assessed by western blot in healthy and MetS. Receptor levels of (D) LgR6, a receptor for Mar1, (E) ChemR23, a receptor for RvE1, and (F) GCPR18, a receptor for RvD2 were examined in lung tissue to determine disease-related differences in AgNP-induced inflammatory response. (G-I) Representative western blot images of LgR6, ChemR23, and GCPR18. Values are expressed as mean ± SEM (n = 6–8/group). * denotes significant differences due to AgNP exposure, # denotes significant differences between healthy and MetS mouse models (p < 0.05).