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. 2021 Oct 25;6:126. doi: 10.1038/s41541-021-00387-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representation of Ab1245-BG505-8ANC195 structure. Fabs are shown in cartoon, BG505 is shown as surface, and glycans are shown as sticks. Within BG505, gp120 is light gray and gp41 is dark gray. The Ab1245 V_H-V_L is dark pink (heavy chain) and light pink (light chain); 8ANC195 Fabs are dark green (heavy chain) and light green (light chain). b Side view (left) and view looking up from the trimer base (right) of density map for 3.7 Å Ab1245-BG505-8ANC195 complex. Colors as in (a). c Close-up view of Ab1245 V_H-V_L domains (cartoon) interacting with gp120-gp41 interface with highlighted CDRH3 (cyan). N-linked glycans are light gray (gp120), dark gray (gp41), or yellow (N88_gp120 and N241_gp120 glycans) spheres. d Cartoon representation of VRC34-AMC011 SOSIP structure (PDB 6NC3) from the same view as c (left) and a different view from above the trimer (right). VRC34 heavy and light chains (PDB 6NC3) are dark and light purple, respectively.