TABLE 1.

Factors regulating WWP1 mRNA levels.

Factor	Molecule type	Effect on WWP1 mRNA level	Mechanism	References
TGFβ	Extracellular signaling molecule	↑	unknown	Chen and Matesic, 2007
TNFα	Extracellular signaling molecule	↑	unknown	Zhao et al., 2011
p53	Transcription factor	↑	transactivation	Li Y. et al., 2008
MYC	Transcription factor	↑	transactivation	Lee et al., 2019
miR-452	microRNA	↓	Destabilizing WWP1 mRNA	Goto et al., 2016
miR-15b	microRNA	↓	Destabilizing WWP1 mRNA	Li et al., 2020
miR-21	microRNA	↓	Destabilizing WWP1 mRNA	Tao et al., 2018
miR-30a-5p	microRNA	↓	Destabilizing WWP1 mRNA	Zhao et al., 2019
miR-129-5p/3p	microRNA	↓	Destabilizing WWP1 mRNA	Ma et al., 2018
miR-142	microRNA	↓	Destabilizing WWP1 mRNA	Tu et al., 2017; Wang et al., 2021
miR-584-5p	microRNA	↓	Destabilizing WWP1 mRNA	Li et al., 2017
SNHG12	Long non-coding RNA	↑	Sponging miR-129-5p and stabilizing WWP1 mRNA	Li et al., 2019
circWAC	Circular RNA	↑	Sponging miR-142 and stabilizing WWP1 mRNA	Wang et al., 2021