Figure 3.

Identifying environmental perturbations impacting significant GWAS loci

GWAS enrichment results for each group of complex traits from the GWAS Catalog. Each point represents a perturbation-cell-line combination that passes the FDR < 10% cut-off; the color of the point indicates the cell line and the shading color within each panel indicates the perturbation category from Figure 1A. The y axis represents the −log₁₀(p value) of Fisher’s exact test and the size indicates the odds ratio for the enrichment of GWAS hits of each group of traits from the GWAS Catalog. Numerical results are reported in Data S10. Results for specific traits, rather than groups of traits, are displayed in Figure S5.