Table 1.

Replicated associations with white blood cell traits in TOPMed

Trait	Chr	Position	Ref	Alt	rsID	Annotation	Betaa	SE	p value	Overall AFb	EA AFc	EA β	EA p	AA AFd	AA β	AA p	HA AFe	HA β	HA p	Replication β	Replication p
EOS	X	1256294	A	G	rs28532112	intergenic CSF2RA	−0.009	0.001	1.08 × 10−11	0.2578	0.1579	−0.0097	2.49 × 10−5	0.4276	−0.0055	0.0079	0.2571	−0.0139	0.0003	−0.0901	4.82 × 10−6
LYM	11	5227002	T	A	rs334	missense HBB	−0.237	0.026	2.76 × 10−20	0.015	0.0003	0.0396	0.8985	0.0423	−0.19	3.30 × 10−14	0.012	−0.2797	1.41 × 10−6	−0.1737	2.88 × 10−13
MON	21	15012619	A	G	rs28574812	intronic NRIP1	−0.011	0.002	1.54 × 10−10	0.287	0.1592	−0.0109	0.0006	0.5318	−0.0102	0.0002	0.245	−0.0101	0.0194	−0.0231	2.19 × 10−7
MON	9	88921159	C	A	rs28450540	intergenic S1PR3	−0.035	0.004	3.65 × 10−17	0.04	0.0009	−0.0399	0.3284	0.117	−0.033	3.44 × 10−12	0.0245	−0.0532	5.19 × 10−5	−0.2161	2.64 × 10−25
WBC	11	132819661	GAC	G	rs79353195	intronic OPCML	−0.135	0.025	4.00 × 10−8	0.0629	0.0465	−0.1285	0.0006	0.0658	−0.1072	0.0283	0.0629	−0.1353	4.00 × 10−8	−0.0207	0.0159
WBC	21	15001515	A	T	rs2823002	intronic NRIP1	−0.079	0.014	3.75 × 10−8	0.3198	0.1625	−0.0823	0.0001	0.6943	−0.0828	0.0021	0.3198	−0.0794	3.75 × 10−8	−0.0186	0.0002
WBC	3	132710603	C	T	rs62292471	intronic NPHP3	0.1139	0.02	1.07 × 10−8	0.0965	0.1218	0.1104	5.64 × 10−6	0.025	−0.0009	0.9906	0.0965	0.1139	1.07 × 10−8	0.0223	7.40 × 10−5

^aEffect sizes are represented in transformed trait values.

^bAF = allele frequency

^cEA = European American

^dAA = African American

^eHA = Hispanic American