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. 2021 Oct 25;12:6161. doi: 10.1038/s41467-021-26409-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Phylogenetic trees based on the amino acid sequences of the WSEIV glycoproteins and the representative influenza A and B HAs (A) and NAs (E) obtained from GISAID are shown. The scale bar indicates a 5% difference in amino acid sequence. Amino acid conservation of the WSEIV HA (B) and WSEIV NA (F) relative to influenza B virus HA and NA are represented by the residues highlighted in red. The structure and sequence of influenza virus strain B/Brisbane/60/2008 were used as a template for comparison. Pairwise alignments of the WSEIV HA and NA are displayed against influenza B/Malaysia/2506/2004 virus HA and NA, (C) and (G), respectively. Identical residues are indicated by asterisks. Functionally and antigenically relevant features have been annotated. Recombinantly expressed HAs (D) and NAs (H) of influenza B/Malaysia/2506/2004 virus and WSEIV were visualized on an SDS–PAGE gel in deglycosylated and non-deglycosylated conditions. A representative of two independent assays is shown. Structures are based on PDB# 4FQM⁵⁰ for HA and PDB# 4CPL⁵¹ for NA.