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. 2021 Oct 25;11:21004. doi: 10.1038/s41598-021-99957-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Models of physiological linkage. Arrows indicate potential physiological linkage from senders to receivers: senders’ physiological responses predict the physiological responses of receivers at a following time interval. (A) We examine how much participants are receivers of physiological linkage (i.e., how much other people’s physiological responses predict participants’ physiological responses) based on the drug they received and the role of senders. (B) We examine how much facilitators are receivers of physiological linkage (i.e., how much other people’s physiological responses predict facilitators’ physiological responses) based on the drug that participants in their cohort received and the role of senders.