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. 2021 Oct 25;12(11):997. doi: 10.1038/s41419-021-04301-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Immunohistochemical analysis of p62 in normal tissue (top), low grade (middle), and high grade (bottom) HNSCC. Scale bar, 50 μm. b Immunohistochemical analysis of cytosolic and nuclear p62 localization corresponding to tumor progression. Scale bar, 50 μm. c Frequency of nuclear p62 in normal tissues and low, moderate, and high-grade HNSCC as assessed by expression levels (score 0–3), analyzed by Chi-square test, p = 0.025. d Frequency of cytoplasmic p62 in normal tissues and low, moderate, and high-grade HNSCC as assessed by expression levels (score 0–3), analyzed by Chi-square test, p < 0.001. e Frequency of overall p62 in normal tissues and low, moderate, and high-grade HNSCC as assessed by expression levels in both nucleus and cytoplasm (score 0–3), analyzed by Chi-square test, p = 0.001.