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. 2021 Oct 25;12(11):997. doi: 10.1038/s41419-021-04301-7

Fig. 4. YOK1104-mediated p62 activation promotes radiotoxicity in HPV(-) via caspase activation in a p62-dependent manner.

Fig. 4

a Clonogenic cell survival assay of HPV(-) HNSCC cell line UM19 and HPV( + ) lines (UP090 and UP154) in the absence or presence of 5 μM YOK1104 at the indicated radiation doses (*p < 0.05, **p < 0.01, ns non-significant). b Clonogenic cell survival assay of control and p62 KD WSU12 cells in the absence or presence of 5 μM YOK1104 at indicated radiation doses. c Immunoblot analysis of p62 in HPV(-) WSU12 cells transfected with control (Scramble) or three independent vectors targeting p62 mRNA (sh p62-(#94, #95, #97). d Caspase-3 (DEVDase)-like activity was measured in control and p62 KD (#94, #95, #97) WSU12 cells treated with 5 μM YOK1104 and/or 6 Gy XRT (*p < 0.05, ns non-significant).