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. 2021 Oct 25;4:1223. doi: 10.1038/s42003-021-02757-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The figures from the left side to the right, show an ISC that is divided once generating one self-renewal ISC and one EB with the activated Notch signaling. Notch signaling gradually increased in this EB in the intestines of young and healthy flies. This process could take more than 3 days. Later on, there were two distinct EB statuses depending on the local physiology: (1) A “differentiation-poised” EB status, corresponding to no EC damage nearby. Notch activation in this “differentiation-poised” EB could be even decreased due to the detachment from the ISC. (2) A “differentiation-activated” EB status, corresponding to a damaged EC nearby. ISC proliferation and Notch activation in EBs were dramatically increased. The local EC renew could be thus achieved in less than one day.