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. 2021 Oct 25;11:20989. doi: 10.1038/s41598-021-00344-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Seasonal variation of serum 25(OH)D levels and its effect on the sampling of relapse/remission patients. The scatter-plot (top-left panel) illustrates the seasonal variation in serum 25(OH)D levels among all MS patients by sampling month and accompanied by the proportion sampled during relapse and of male sex for each month below (bottom-left panels). A smoothed fitted line (dotted, loess method) with 95% confidence interval (grey interval) are plotted along with fitted periodic regression model of sin(2πx/12) + cos(2πx/12) (solid). The distribution of both unadjusted and seasonal variation adjusted serum 25(OH)D levels are illustrated on the right panels (dot plots) along the reported significance between groups as determined by Student t-test.