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. 2021 Oct 25;11:20977. doi: 10.1038/s41598-021-00337-z

Table 3.

The disease-specific or trans-diagnostic relationship between fatigue severity and the predisposing and associated factors.

Disease-specific versus trans-diagnostic model Model A Model B Model C
F(df) p value F(df) p value F(df) p value
Specific chronic disease* 10.660 (14)  < 0.001 2.567 (14) 0.001 0.814 (14) 0.655
Sex 7.539 (1) 0.006 0.909 (1) 0.340
Education level 34.694 (2)  < 0.001 3.267 (2) 0.038
Household composition 7.286 (4)  < 0.001 0.330 (4) 0.858
Partner 0.964 (1) 0.326 1.986 (1) 0.159
Work situation 2.182 (1) 0.140 3.514 (1) 0.061
Smoking 5.228 (1) 0.022 0.266 (1) 0.606
Depressive disorder 324.275 (1)  < 0.001 64.908 (1)  < 0.001
Anxiety disorder 434.870 (1)  < 0.001 53.645 (1)  < 0.001
Bodily pain that hampers in performing activities 394.341 (1)  < 0.001 66.264 (1)  < 0.001
Leisure-time sports activities 302.561 (1)  < 0.001 64.434 (1)  < 0.001
Age 225.963 (1)  < 0.001 46.319 (1)  < 0.001
BMI 108.504 (1)  < 0.001 15.192 (1)  < 0.001
Diastolic blood pressure 2.607 (1) 0.106 2.446 (1) 0.118
Resting heart rate 22.245 (1)  < 0.001 20.845 (1)  < 0.001
Neuroticism facets of anger/hostility, self-consciousness, impulsivity, and vulnerability 865.091 (1)  < 0.001 148.417 (1)  < 0.001
No. of people in household 1.486 (1) 0.223 1.725 (1) 0.189
Disease × sex 0.923 (14) 0.532
Disease × education level 1.049 (28) 0.395
Disease × household composition 0.935 (54) 0.610
Disease × partner 0.950 (13) 0.499
Disease × work situation 1.351 (14) 0.168
Disease × smoking 1.343 (14) 0.173
Disease x depressive disorder 1.834 (14) 0.029
Disease x anxiety disorder 1.785 (14) 0.035
Disease × bodily pain that hampers in performing activities 1.015 (14) 0.435
Disease × leisure-time sports activities 0.362 (14) 0.985
Disease × age 1.087 (14) 0.364
Disease × BMI 1.060 (14) 0.390
Disease × diastolic blood pressure 1.364 (14) 0.162
Disease × resting heart rate 1.505 (14) 0.100
Disease × neuroticism facets of anger/hostility, self-consciousness, impulsivity, and vulnerability 0.741 (14) 0.734
Disease × No. of people in household 0.506 (14) 0.931

no. number, df degrees of freedom, BMI body mass index

*The factor ‘specific chronic disease’ reflects the participants with single-morbidity, entered as a categorical variable with 15 categories (each category reflecting a specific chronic disease with no intrinsic order). Model A: explores the impact of the main effect of ‘specific chronic disease’ on fatigue severity. Model B: investigates the main effects of ‘specific chronic disease’ and the predisposing and associated factors (predictors) on fatigue severity. Model C: studies the impact of the main effects plus the interaction effect between ‘specific chronic disease’ and the predisposing and associated factors on fatigue severity.