Table 3.
Summary of sensitivity analysis for overall survival and 5-year survival rates.
| Variables | 5-year survival rate | OS | ||||||
|---|---|---|---|---|---|---|---|---|
| Data sets* | Effect estimate † | P value | I2 | Data sets* | Effect estimate † | P value | I2 | |
| Adenocarcinoma | 2 (464) | 0.540 (0.416–0.702) | <0.001 | 0% | 2 (464) | 0.517 (0.376–0.711) | <0.001 | 0% |
| Mixed type | 13 (3,100) | 0.829 (0.765–0.898) | <0.001 | 48.6% | 12 (4,981) | 0.755 (0.671–0.895) | <0.01 | 31.5% |
| Publication year >2010 | 11 (2,959) | 0.780 (0.683–0.891) | <0.001 | 75.4% | 12 (5,183) | 0.721 (0.614–0.845) | <0.001 | 48.1% |
| Publication year <2010 | 6 (936) | 0.788 (0.719–0.863) | <0.001 | 0% | 5 (660) | 0.682 (0.529–0.878) | <0.01 | 13.2% |
| No. of patients >100 | 13 (3,650) | 0.791 (0.711–0.879) | <0.001 | 73% | 11 (5,446) | 0.715 (0.611–0.836) | <0.001 | 52.9% |
| No. of patients <100 | 4 (245) | 0.735 (0.622–0.867) | <0.001 | 0% | 6 (397) | 0.691 (0.520–0.918) | <0.05 | 2.3% |
| Mean age >60 | 4 (1,202) | 0.842 (0.762–0.931) | <0.01 | 8.7% | 2 (523) | 0.678 (0.514–0.894) | <0.01 | 0% |
| Mean age <60 | 2 (253) | 0.673 (0.497–0.911) | <0.05 | 13.5% | 3 (2,906) | 0.783 (0.640–0.958) | <0.05 | 0% |
| Adjuvant therapy for all | 3 (595) | 0.880 (0.772–1.003) | 0.055 | 0% | 2 (412) | 0.835 (0.593–1.174) | 0.299 | 0% |
| Adjuvant therapy not for all | 14 (3,300) | 0.757 (0.676–0.848) | <0.001 | 73% | 15 (5,431) | 0.696 (0.598–0.809) | <0.001 | 47.3% |
| Univariable analysis | 9 (2,080) | 0.715 (0.582–0.878) | <0.01 | 84% | 11 (2,232) | 0.681 (0.549–0.844) | <0.001 | 56.8% |
| Multivariable analysis | 5 (958) | 0.780 (0.703–0.866) | <0.001 | 0% | 6 (3,611) | 0.744 (0.645–0.859) | <0.001 | 0% |
| Single N2 station | 5 (1,065) | 0.738 (0.661–0.823) | <0.001 | 0% | 6 (1,150) | 0.682 (0.575–0.809) | <0.001 | 0% |
| Mixed single or multipleN2 station | 12 (2,830) | 0.808 (0.726–0.899) | <0.001 | 66.4% | 11 (4,693) | 0.722 (0.598–0.872) | <0.01 | 51.7% |
*
Values in parentheses are the number of patients.
†
Values are hazard ratios (HRs) 95% CIs for OS; HRs below 1 favor skip N2, whereas values are odds ratio (ORs) 95% CIs for 5-year survival rate; ORs below 1 favor skip N2.