| Rheumatoid arthritis |
 Mast cell mediators promote immune cell recruitment and angiogenesis
Mast cells increased in synovial compartments |
Skin, lung, Hodgkin’s and non-Hodgkin’s lymphoma |
Mellemkjaer et al., 1996; Lee et al., 2002, 2013; Robbie-Ryan and Brown, 2002; Askling et al., 2005; Hueber et al., 2010; Xu et al., 2010; Walker et al., 2012; Kashiwakura et al., 2013; Rivellese et al., 2015; Malmström et al., 2017; Aletaha and Smolen, 2018; Klein et al., 2018; Smolen et al., 2018; Min et al., 2020
|
| Multiple sclerosis |
Mast cell mediators promote vascular permeability and immune cell recruitment
Mast cells present at sites of inflammatory demyelination
Mast cell density is increased in MS plaques |
Respiratory, urinary, breast, CNS, non-melanoma skin cancer |
Dietsch and Hinrichs, 1989; Galli et al., 1992; Brenner et al., 1994; Rozniecki et al., 1995; Ibrahim et al., 1996; Dimitriadou et al., 2000; Secor et al., 2000; Brown et al., 2002; Lock et al., 2002; Rottem and Mekori, 2005; Couturier et al., 2008; Sayed et al., 2008; Kingwell et al., 2012; Karagkouni et al., 2013; Sun et al., 2014; Grytten et al., 2020; Magyari and Sorensen, 2020
|
| Type 1 diabetes |
Increase in pancreatic mast cell density that correlates with apoptotic beta cells |
Stomach, lung, liver, pancreas, kidney, endometrium, ovarian |
Esposito et al., 2001; Geoffrey et al., 2006; Vigneri et al., 2009; Martino et al., 2015; Solt and Burris, 2015; Betto et al., 2017; Sona et al., 2018; Suh and Kim, 2019
|
| Inflammatory bowel disease |
Increased mast cell density in ileum
Increased histamine and histamine metabolites |
Colorectal cancer, small bowel adenocarcinoma, intestinal lymphoma, anal cancer, cholangiocarcinoma |
Lloyd et al., 1975; Fox et al., 1990; Nolte et al., 1990; Braegger et al., 1992; Traynor et al., 1993; Crowe et al., 1997; Gelbmann et al., 1999; Lilja et al., 2000; Oprins et al., 2000; Weidenhiller et al., 2000; Sasaki et al., 2002; Winterkamp et al., 2002; He, 2004; Jacob et al., 2005; Strober et al., 2007; Bischoff, 2009; Kurashima et al., 2013; Axelrad et al., 2016
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