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. 2021 Oct 25;12(11):998. doi: 10.1038/s41419-021-04278-3

Fig. 3. ZBTB38 binds the promoters and regulates the expression of its target genes in DU145 cell.

Fig. 3

A Genome distribution of HA- ZBTB38 ChIP-seq peaks in DU145 cells. B Signal plot of HA-ZBTB38 ChIP-seq signals in DU145 cells. C Volcano plot for DEGs in ZBTB38 overexpression DU145 RNA-seq. Right panel: the overlap of ChIP-seq peaks and DEGs. D GO analysis (biological process, BP) of downregulated genes after ZBTB38 overexpression in DU145 cells using the DAVID program. E A representative snapshot of ZBTB38 ChIP-seq and RNA-seq signals located in DKK1 gene locus. F RT-qPCR analyses of the mRNA levels of DKK1 gene in the DU145 cells with a control vector or ZBTB38 overexpression or ZBTB38 knockdown. (**P < 0.01, ***P < 0.001).